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I receive a lot of inquiries to my account. I'm going to try to share them with the community in the hope that any information that is shared can help many others. A member recently contacted me and asked the following: "I am a Biomaterials and Tissue Engineer by profession and recently got into 3d printing of medical implants. I would be greatly obliged if you could please advice me on designing 'cranial mesh' My task is to design titanium based cranial mesh. I would like to know if you can suggest me any tutorial on the same." Another member asks, " I am a resident in neurosurgery in Brazil and I have a dream to allow cheap cranioplasty for those in need that depend on Brazilian public health system. If you have some sort of tutorial using free software to make those prosthetic cranial grafts of a cheap way to make a mold out of it I will be glad to hear from you. I am planning on buying the ultimaker 2 printer which allows direct PEEK print and also PLA print for mold to go through autoclave." I must admit that I have limited experience with craniofacial implants. I know that the physicians at Walter Reed Army Medical Center in Bethesda Maryland are doing pioneering work in the field. Regarding making titanium-based implants I am unaware of any tutorials, but a search on Pubmed has yielded a few helpful articles. Here is one https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073471/ From what I have seen most of these implants are designed using the Mimics system by Materialise. Regarding the low-cost solution for cranial implants, I'm not familiar with any freeware software that specifically does implants. From the hardware perspective, you may want to consider a Form 2 stereolithographic printer in addition to the Ultimaker 2 (FYI, there is a new Ultimaker 3 printer out). Formlabs, the makers of the Form 2 have a tutorial on using their printer to make molds for casting. https://formlabs.com/blog/3d-printing-for-injection-molding/ Formlabs has a dental biocompatible resin that I know some hospitals (Mayo Clinic) are using for in-surgery cutting guides. I heard them talk about that at a conference I recently attended. Whatever you do, make sure you follow the health safety rules in your country and take all necessary steps for patient safety.