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About This File

This model is the bilateral thigh rendering of a 49-year-old male with a right medial thigh undifferentiated pleomorphic malignant fibrous histiocytoma (MFH). The patient underwent neoadjuvant radiotherapy, surgery, and adjuvant chemotherapy treatment and was found to have a high-grade lesion at the time of diagnosis. Metastases to his lungs were also found at diagnosis. The patient is still living with the disease at 2 years since diagnosis. This is an STL file created from DICOM images of his CT scan which may be used for 3D printing.

 

Undifferentiated pleomorphic MFH has more recently been classified as Undifferentiated Pleomorphic Sarcoma. This is the most common soft tissue sarcoma in late adulthood, commonly occurring between 55 to 80 years old and most commonly in Caucasian males. Clinically, it presents as a slow growing mass in the extremities. Biopsy of the lesion demonstrates, as its name implies, an undifferentiated and pleomorphic appearance. Pleomorphism is the pathologic description of cells and nuclei with variability in size, shape and staining, which is characteristic of a malignant neoplasm. “Undifferentiated” means that the tissue does not appear like an identifiable tissue structure. Treatment consists of wide resection and radiation. Chemotherapy is added in cases of metastasis, most commonly to the lung. Five-year survival is between 35-60% depending on grade of tumor and metastases.

 

This model was created from the file STS_021.




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