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This model is the right thigh muscle rendering of a 56 year old male with a pleomorphic leiomyosarcoma of the anterior compartment of the right thigh. The patient underwent neoadjuvant radiotherapy, surgery, and adjuvant chemotherapy treatment and was found to have an intermediate grade lesion at the time of diagnosis.  However, the tumor metastasized to his lungs, and the patient died 2.5 years after diagnosis. This is an STL file created from DICOM images of his CT scan which may be used for 3D printing.

 

Leiomyosarcomas are aggressive soft tissue malignancies that are thought to arise from the smooth muscle cells lining small blood vessels. Pleomorphism is the pathologic description of cells and nuclei with variability in size, shape and staining, which is characteristic of a malignant neoplasm. Pleomorphic leiomyosarcoma is an aggressive form of leiomyosarcoma, accounting for approximately 10% of these tumors. The mean age of occurrence is 58 years old, with a range from 31-89 years. These usually occur in the extremities, but may also present in the retroperitoneum/abdominal cavity, chest/abdominal wall, and, occasionally, the scalp. On biopsy, the definition of pleomorphic leiomyosarcoma is the presence of pleomorphic cells in at last two-thirds of the cut section and at least one section of positive staining for smooth muscle. Treatment is early wide resection of the primary lesion and neo-adjuvant or adjuvant chemotherapy and radiation. Tumors may metastasize to the lung. A large primary tumor and presence in the retroperitoneal cavity are poor predictive factors, and about 65% of patients succumb to the disease.

 

This model was created from the file STS_014.


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